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Predictive value of a proteomic signature in patients with non-small-cell lung cancer treated with second-line erlotinib or chemotherapy (PROSE): a biomarker-stratified, randomised phase 3 trial.
Oncologists should be able to readily glean the information needed to select appropriate therapy, and to explain the result to their patients.
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Small-Cell Lung Cancer Treated with EGFR Tyrosine Kinase Inhibitors.
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In the Phase III program, the major side effects were flushing, Corporategastrointestinal disorders, headache and nasopharyngitis.
For time to progression on TKI, distribution plots were compared with Wilcoxon rank tests.
Moos R, Thuerlimann BJ, Aapro M, et al: Pegylated liposomal doxorubicin-associated hand-foot syndrome: Recommendations of an international panel of experts.
Patient with Advanced Lung Adenocarcinoma Effectively Treated with Gemcitabine Plus Vinorelbine After Failure with Gefitinib.
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Tumor response was assessed as complete response (CR), partial response (PR), no change (NC) or progressive disease (PD) according to the World Health Organization criteria.
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In other words, patients that expressed a large amount of epidermal growth factor receptor had better results with erlotinib than those patients with lower amounts of the receptor protein.
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If gefitinib is administered as second-line or third-line treatment, patients may miss the opportunity to receive treatment with gefitinib because of rapidly progressive disease during or after first-line treatment.
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Personalizing therapy in an epidermal growth factor receptor-tyrosine kinase inhibitor resistant non-small cell lung cancer using P-00299804 and Trastuzumab.
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Besides this thorough examination of the drugs ingredients and performance, the FDA also conducts periodic inspections of the manufacturing plants to ensure there are no changes in the approved drugs quality.
Gefitinib was supplied by Polymed Therapeutics, Inc.
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